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PHMSA is publishing HM-266 Advance Notice of Proposed Rulemaking (ANPRM) to solicit stakeholder input on the transportation of hazardous materials in highly automated transportation systems. The HMR was primarily designed with traditional transportation methods in mind. The advent of highly automated transportation systems, ranging in possibility from drones and delivery robots to fully automated freight trucks, introduces new challenges and opportunities that were not anticipated by the original regulatory framework of the HMR. The emergence of this new technology has the potential to transform how hazardous materials are transported while potentially enhancing safety, efficiency, and reliability. This shift warrants a comprehensive review of the requirements in the Hazardous Materials Regulations (HMR; 49 CFR parts 171–180). PHMSA is publishing this ANPRM to solicit feedback that can be used in performing that review.